Whenever I try to use Oekaki Shi Painter for my Anime Art, it always turns out horribly wrong, while everyone elses looks amazing. Something seems to go wrong when I use it, can someone please teach me?

Err.. from the looks of your user board, you only use Lascaux Sketch.

The only tip I can provide for you is usign the pen tool rather than the pencil tool. Play around with it and see what you can figure out from it.

I was hoping to get a comment from you, you're probably the best Anime painter I've ever seen. I will try and once I have finished, I'll put it up here.

For lineart you can use the pen tool and then fix the lines with the soft eraser, or use the airbrush on a higher opacity if you're patient enough. When it comes to coloring, pen is good for putting down the base colors, and using a mix of tools for the shading is a good idea. Just experiment with it and see what seems to suit you best.

Is it possible to use layers on it?

Of course! All of the applets have layers.

thought bbs doesn't have enough layers.

http://cellosoft.com/2draw/view/73865/
My picture